Christophe Hézode Selected Research

N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamide

1/2016	Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies.
9/2015	Early virological assessment during telaprevir- or boceprevir-based triple therapy in hepatitis C cirrhotic patients who failed a previous interferon based regimen - The ANRS CO20-CUPIC study.
1/2015	Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study.
7/2014	Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis.
2/2014	Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection.
11/2013	Effects of ribavirin dose reduction vs erythropoietin for boceprevir-related anemia in patients with chronic hepatitis C virus genotype 1 infection--a randomized trial.
9/2013	Management of anaemia and other treatment complications.
2/2013	How to optimize HCV therapy in genotype 1 patients with cirrhosis.
2/2012	Boceprevir and telaprevir for the treatment of chronic hepatitis C: safety management in clinical practice.
1/2012	Antiviral strategies in hepatitis C virus infection.

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Christophe Hézode Research Topics

Disease

50	Infections 06/2021 - 07/2007
31	Fibrosis (Cirrhosis) 01/2020 - 01/2002
29	Chronic Hepatitis C 01/2019 - 06/2002
9	Hepatitis C 10/2018 - 10/2006
6	Liver Diseases (Liver Disease) 10/2018 - 05/2007
5	Chronic Hepatitis B 10/2016 - 05/2007
4	Pruritus (Itching) 03/2014 - 04/2009
4	Exanthema (Rash) 03/2014 - 04/2009
3	Virus Diseases (Viral Diseases) 01/2017 - 06/2015
3	Anemia 03/2014 - 04/2009
2	Persistent Infection 01/2020 - 04/2009
2	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 06/2010
2	Fatigue 10/2018 - 03/2014
2	Coinfection 09/2018 - 12/2009
1	Chronic Disease (Chronic Diseases) 10/2018
1	Mental Disorders (Mental Disorder) 09/2018
1	Hepatitis 09/2018
1	Substance-Related Disorders (Drug Abuse) 09/2018
1	Hepatitis B 09/2018
1	Hemorrhage 01/2017
1	Hemoglobinopathies 01/2017
1	Nausea 03/2014
1	Headache (Headaches) 03/2014
1	Cicatrix (Scar) 02/2012
1	Dermatitis 02/2012
1	Eczema 02/2012
1	Disease Progression 06/2010
1	Body Weight (Weight, Body) 04/2009
1	Hyperglycemia 02/2008
1	Liver Cirrhosis (Hepatic Cirrhosis) 12/2004
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 10/2002

Drug/Important Bio-Agent (IBA)

35	Ribavirin (Virazole)FDA LinkGeneric 02/2018 - 04/2005
24	Antiviral Agents (Antivirals)IBA 01/2019 - 07/2007
20	InterferonsIBA 01/2020 - 12/2009
15	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2002
13	telaprevirIBA 01/2016 - 04/2009
11	daclatasvirIBA 06/2017 - 09/2012
10	N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA 01/2016 - 01/2012
8	Protease Inhibitors (Protease Inhibitor)IBA 01/2018 - 02/2014
7	peginterferon alfa-2a (Pegasys)FDA Link 01/2016 - 10/2006
6	SofosbuvirIBA 01/2021 - 05/2014
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 06/2010
4	Proteins (Proteins, Gene)FDA Link 01/2017 - 12/2004
4	Ritonavir (Norvir)FDA Link 01/2016 - 01/2015
3	elbasvirIBA 01/2019 - 01/2017
3	grazoprevirIBA 01/2019 - 01/2017
3	SimeprevirIBA 06/2017 - 02/2016
3	NucleosidesIBA 01/2017 - 04/2013
3	NucleotidesIBA 01/2017 - 04/2013
3	paritaprevirIBA 01/2016 - 06/2015
3	ombitasvirIBA 01/2016 - 06/2015
3	asunaprevirIBA 05/2015 - 01/2013
3	Interferon-alpha (Interferon Alfa)IBA 07/2007 - 04/2005
2	Hepatitis B Surface Antigens (HBsAg)FDA Link 06/2021 - 04/2013
2	Biomarkers (Surrogate Marker)IBA 07/2015 - 12/2004
2	8- cyclohexyl- N- ((dimethylamino)sulfonyl)- 1,1a,2,12b- tetrahydro- 11- methoxy- 1a- ((3- methyl- 3,8- diazabicyclo(3.2.1)oct- 8- yl)carbonyl)cycloprop(d)indolo(2,1- a)(2)benzazepine- 5- carboxamideIBA 05/2015 - 02/2014
2	Erythropoietin FDA Link 11/2013 - 09/2013
2	Hepatitis B e AntigensIBA 01/2009 - 05/2007
2	Alanine Transaminase (SGPT)IBA 05/2007 - 01/2002
1	Oral ContraceptivesIBA 01/2019
1	glecaprevir and pibrentasvirIBA 01/2019
1	Ethinyl Estradiol (Estinyl)FDA LinkGeneric 01/2019
1	Illicit Drugs (Recreational Drugs)IBA 09/2018
1	Hemoglobins (Hemoglobin)IBA 01/2017
1	Tenofovir (Viread)FDA Link 10/2016
1	AntigensIBA 04/2016
1	Hepatitis C AntibodiesIBA 01/2016
1	peginterferon lambda-1aIBA 01/2016
1	2'- fluoro- 2'- methyl- 3',5'- diisobutyryldeoxycytidineIBA 01/2016
1	velpatasvirIBA 12/2015
1	alisporivirIBA 10/2015
1	N 30IBA 06/2015
1	sofosbuvir drug combination ledipasvirIBA 04/2015
1	danoprevirIBA 01/2015
1	ApolipoproteinsIBA 10/2014
1	beta 2-Glycoprotein I (Apolipoprotein H)IBA 10/2014
1	InterleukinsIBA 02/2014
1	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2012
1	EmollientsIBA 02/2012
1	HCV NS3-4A Protease InhibitorsIBA 01/2012
1	Caffeine (No Doz)FDA LinkGeneric 06/2011
1	adefovir dipivoxil (Hepsera)FDA Link 01/2009
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2009
1	Viral ProteinsIBA 07/2008
1	adefovirIBA 05/2007
1	Lamivudine (Epivir)FDA Link 05/2007
1	Tissue Inhibitor of Metalloproteinase-1IBA 12/2004
1	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)IBA 12/2004
1	Hyaluronic Acid (Hyaluronan)IBA 12/2004
1	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 10/2002

Therapy/Procedure

26	Therapeutics 01/2021 - 04/2005
4	Liver Transplantation 01/2017 - 01/2002
3	Duration of Therapy 02/2018 - 02/2015
2	Opiate Substitution Treatment 01/2019 - 09/2018
2	Drug Tapering 11/2013 - 08/2002
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/2019
1	Aftercare (After-Treatment) 10/2018
1	Ambulatory Care (Outpatient Care) 09/2018
1	Transplantation 10/2002
1	Organ Transplantation 10/2002